Thomas is a Houston Native who grew up playing football in Missouri City. Thomas attended Oklahoma State University where he was selected as first team selection on the College Football All-America Team in 1985 and 1987 and also a Heisman candidate his senior year.
Drafted in the first round of the 1988 NFL draft by the Buffalo Bills, Thomas was a key component in the offense that included Jim Kelly and Andre Reed, which lead the Bills to four straight Super Bowl appearances. Thomas was selected to 5 straight Pro-Bowls from 1989-1993. Thurman Thomas played in the NFL for 13 season and still hold the all-time Buffalo Bills rushing record with 11,938 yards and the team record for yards from scrimmage with 16,279 over 12 years. Thomas is also the only player in the history of the NFL to lead the league in total yards from scrimmage for four consecutive season.